Sex ratio and heterozygote advantage in cystic fibrosis families

  • Pritchard D
  • Hickman G
  • Nelson R
  • 3


    Mendeley users who have this article in their library.
  • 8


    Citations of this article.


The families of aunts and uncles of cystic fibrosis (CF) patients were compared with one another and with controls in order to test claims of increased fertility and sex ratio in families containing the CF allele and to identify the more fertile sex. Uncles' families were found to contain a significant excess of sons, particularly at primiparous births, as well as a significantly increased sex ratio. Reanalysis of published records of CF sibships confirmed the effect of parity on sex ratio. The families of uncles were also exceptional in exceeding the size intended, although their mean size was not raised significantly. It is suggested that these effects could be related to an interaction between CF-related, paternally-derived antigens and the maternal immune system.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • D. J. Pritchard

  • G. R. Hickman

  • R. Nelson

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free