SH2 and SH3 domains are found in a variety of cytoplasmic signalling proteins that couple growth factor receptors to intracellular signal-transduction pathways. SH2 domains, in particular, direct the interactions of signalling proteins with activated receptor tyrosine kinases and other phosphoproteins. The ≈95-amino-acid SH2 domain appears to be a good example of a protein module. This review summarizes recent work on the structure and function of SH2 and SH3 domains. © 1992.
CITATION STYLE
Pawson, T. (1992). SH2 and SH3 domains. Current Opinion in Structural Biology, 2(3), 432–437. https://doi.org/10.1016/0959-440X(92)90235-Y
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