SH2 and SH3 domains

  • Pawson T
  • 96

    Readers

    Mendeley users who have this article in their library.
  • 32

    Citations

    Citations of this article.

Abstract

SH2 and SH3 domains are found in a variety of cytoplasmic signalling proteins that couple growth factor receptors to intracellular signal-transduction pathways. SH2 domains, in particular, direct the interactions of signalling proteins with activated receptor tyrosine kinases and other phosphoproteins. The ≈95-amino-acid SH2 domain appears to be a good example of a protein module. This review summarizes recent work on the structure and function of SH2 and SH3 domains. © 1992.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Tony Pawson

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free