SH2 and SH3 domains are found in a variety of cytoplasmic signalling proteins that couple growth factor receptors to intracellular signal-transduction pathways. SH2 domains, in particular, direct the interactions of signalling proteins with activated receptor tyrosine kinases and other phosphoproteins. The ≈95-amino-acid SH2 domain appears to be a good example of a protein module. This review summarizes recent work on the structure and function of SH2 and SH3 domains. © 1992.
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