Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins.

  • Aplin A
  • Howe A
  • Alahari S
 et al. 
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I. Introduction II. Families of Cell Adhesion Receptors A. Overview B. Integrins C. Cadherins D. Immunoglobulin-Cell Adhesion Molecule Superfamily E. Selectins III. The Components of Adhesive Junctions A. Integrin Containing Focal Contacts 1. Cytoskeletal proteins 2. Transmembrane proteins: tetraspanners, integrin-associated protein 50, caveolin 3. Cytoplasmic integrin-binding proteins 4. Interactions with Integrin Heterodimers. B. Other Adhesive Junctions 1. Cadherin-mediated adherence junctions 2. Junctions containing ezrin/radixin/moesin proteins IV. Direct Signal Transduction by Integrins: Activation of Tyrosine Kinases A. Introduction B. Focal Adhesion Kinase-Mediated Events 1. Linkage to integrin signaling 2. Mechanism of activation 3. The role of Src in focal adhesion kinase signaling 4. Other focal adhesion kinase-binding proteins 5. Inhibition of focal adhesion kinase activity 6. Focal adhesion kinase substrates 7. Focal adhesion kinase function 8. Focal adhesion kinase summary C. Focal Adhesion Kinase Family Members D. Src Family Members 1. Activation of Src family members downstream of beta1 integrins 2. Activation of Src family members downstream of beta2 integrins E. Other Tyrosine Kinases Activated by Integrins 1. C-Abl 2. Spleen tyrosine kinase F. Summary V. Direct Signal Transduction by Integrins: Activation of the Mitogen-Activated Protein Kinase Cascade A. Experimental Approaches and Cell Types B. Time Course of Integrin-Mediated Mitogen-Activated Protein Kinase Activation and Its Consequences C. Mechanisms for Integrin-Mediated Mitogen-Activated Protein Kinase Activation 1. Mechanism of growth factor activation of mitogen-activated protein kinase 2. Mechanism of integrin-mediated activation of mitogen-activated protein kinase 3. The role of focal contact hierarchies and cytoskeletal organization in integrin-mediated mitogen-activated protein kinase activation D. Integrin-Mediated Activation of the Jun N-Terminal Kinase/Stress-Activated Protein Kinase Pathway E. Functions of Integrin-Mediated Mitogen-Activated Protein Kinase Activation 1. Transcriptional regulation 2. Cytoplasmic targets 3. Cell adhesion and motility F. Summary VI. Integrins and Rho Family Guanosine 5'-Triphosphatases A. Introduction B. Regulation of Activity C. Proteins that Interact with Rho Family Guanosine 5'-Triphosphatases D. Rho Guanosine 5'-Triphosphatases, Cell Cycle Progression, and Transcriptional Regulation E. Rho Guanosine 5'-Triphosphatases and the Cytoskeleton 1. Lipid metabolism 2. Rho, mitogen-activated protein kinase, and contractility F. Summary VII. Other Aspects of Integrin Signaling A. Signaling by Specific Integrins B. Cross-Talk Between Integrins C. Mechanochemical Aspects of Adhesion Signaling D. Relationships Between Integrin Signaling Pathways VIII. Signaling by Cadherins, Selectins, and Immunoglobulin-Cell Adhesion Molecules A. Cadherin Signaling 1. Cadherins, catenins, adenomatous polyposis coli, and the Wnt pathway 2. Components of the Wnt-cadherin signaling pathway 3. A model for the Wnt-cadherin signaling pathway 4. Other aspects of cadherin signaling B. Signaling by Immunoglobulin-Cell Adhesion Molecules 1. Neural immunoglobulin-cell adhesion molecules 2. Other signaling by immunoglobulin-cell adhesion molecules C. Signaling by Selectins D. Collagen Binding Receptor Tyrosine Kinases E. Summary IX. Adhesion Modulation of Signaling by Soluble Mitogens and Differentiation Factors A. Introduction B. Integrin Modulation of Growth Factor Signaling C. Signal Modulation by Other Cell Adhesion Molecules 1. Neuronal cell adhesion molecules 2. Cadherin-catenin complexes 3. Selectins D Summary X. Cell Adhesion Receptors and the Control of Cell Cycle and Programmed Cell Death A. Cell Adhesion and Cell Cycle Control 1. Overview of the cell cycle machinery 2. Links between signaling pathways and the cell cycle 3. Cell cycle activities regulated by cell adhesion 4. Anchorage regulation of the cell cycle: a role for specific integrins? B. Cell Adhesion and Apoptosis 1. Overview of apoptosis 2. Anchorage regulation of apoptosis XI. Cell Adhesion Receptors and the Regulation of Gene Expression XII. Conclusions Acknowledgments References

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  • a E Aplin

  • a Howe

  • S K Alahari

  • R L Juliano

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