The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specific fashion and thereby influence key features of cellular phenotype. These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets. © 2005, Elsevier Inc.
CITATION STYLE
Lindemann, S. W., Weyrich, A. S., & Zimmerman, G. A. (2005, January). Signaling to translational control pathways: Diversity in gene regulation in inflammatory and vascular cells. Trends in Cardiovascular Medicine. https://doi.org/10.1016/j.tcm.2004.10.004
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