Signaling to translational control pathways: Diversity in gene regulation in inflammatory and vascular cells

  • Lindemann S
  • Weyrich A
  • Zimmerman G
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Abstract

The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specific fashion and thereby influence key features of cellular phenotype. These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets. © 2005, Elsevier Inc.

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Authors

  • Stephan W. Lindemann

  • Andrew S. Weyrich

  • Guy A. Zimmerman

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