A simple approach to risk stratification in adult heart transplantation.

  • Anyanwu A
  • Rogers C
  • Murday A
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OBJECTIVE: While there are numerous reports in the literature of risk factors for graft failure after heart transplantation, simple models for risk stratification are lacking. This study describes a simple method for risk stratification in adult heart transplantation that can be applied when the size of a dataset is insufficient for formal regression modelling. METHODS: Multi-centre prospective cohort study. Fourteen risk factors documented in the literature as increasing post transplant graft failure were used to formulate a model. Risk factors included in the model were recipient age >50 years, pre-operative ventilatory support, pre-operative circulatory support, >1 previous sternotomy, pulmonary vascular resistance >2.5 wood units, male with body surface area >2.5 m2, retransplant, ischaemic time >3.5 h, donor age >45 years, donor inotropic support >10 microg/kg per min dopamine, female donor, ratio donor/recipient body surface area

Author-supplied keywords

  • Adult
  • Age Factors
  • Female
  • Graft Rejection
  • Graft Survival
  • Heart Diseases
  • Humans
  • ISHLT presentation 2011
  • Male
  • Middle Aged
  • Prognosis
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Assessment
  • Risk stratification
  • Sex Factors
  • Tissue Donors
  • Transplantation
  • comparative study
  • heart transplantation
  • multicenter study
  • non-u.s. gov't
  • predictive modelling
  • research support
  • risk factors

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  • A C Anyanwu

  • C A Rogers

  • A J Murday

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