Liver ablation is challenging in high-intensity focused ultrasound (HIFU) because of the presence of ribs and great inhomogeneity in multi-layer tissue. In this study, angular spectrum approach (ASA) has been used in the wave propagation from phased-array HIFU transducer, and diffraction, attenuation and the nonlinearity are accounted for by means of second order operator splitting method. Bioheat equation is used to simulate the subsequent temperature elevation and lesion formation with the formation of shifted focus and multiple foci. In summary, our approach could simulate the performance of phased-array HIFU in the clinics and then develop an appropriate treatment plan.
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