Single nucleotide polymorphism at exon 7 splice acceptor site of OAS1 gene determines response of hepatitis C virus patients to interferon therapy

  • El Awady M
  • Anany M
  • Esmat G
 et al. 
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Abstract

Response to interferon therapy and disease progression in hepatitis C virus (HCV) infected patients differs among individuals, suggesting a possibility of a contribution of host genetic factors. 2'-5'-oligoadenylate synthetase 1 (OAS1), an important component of the innate immune system with a proven antiviral function, may therefore have a relationship with the response to interferon therapy and clinical course of HCV disease. Our aim was to determine the frequency of single nucleotide polymorphism (SNP) at exon 7 splice acceptor site (SAS) of the OAS1 gene in relation to the interferon response and status of HCV infection.

Author-supplied keywords

  • Hepatitis C virus
  • Liver fibrosis
  • OAS1
  • Response to interferon therapy
  • Single nucleotide polymorphism

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Authors

  • Mostafa K. El Awady

  • Mohamed A. Anany

  • Gamal Esmat

  • Naglaa Zayed

  • Ashraf A. Tabll

  • Amr Helmy

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