A single type of progenitor cell maintains normal epidermis

  • Clayton E
  • Doupé D
  • Klein A
 et al. 
  • 462

    Readers

    Mendeley users who have this article in their library.
  • 466

    Citations

    Citations of this article.

Abstract

According to the current model of adult epidermal homeostasis, skin tissue is maintained by two discrete populations of progenitor cells: self-renewing stem cells; and their progeny, known as transit amplifying cells, which differentiate after several rounds of cell division. By making use of inducible genetic labelling, we have tracked the fate of a representative sample of progenitor cells in mouse tail epidermis at single-cell resolution in vivo at time intervals up to one year. Here we show that clone-size distributions are consistent with a new model of homeostasis involving only one type of progenitor cell. These cells are found to undergo both symmetric and asymmetric division at rates that ensure epidermal homeostasis. The results raise important questions about the potential role of stem cells on tissue maintenance in vivo.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Benjamin SimonsUniversity of Cambridge

    Follow
  • Elizabeth Clayton

  • David P. Doupé

  • Allon M. Klein

  • Douglas J. Winton

  • Philip H. Jones

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free