The SIRP family of receptors and immune regulation

  • Barclay A
  • Brown M
  • 127


    Mendeley users who have this article in their library.
  • 182


    Citations of this article.


The immune system must be highly regulated to obtain optimal immune responses for the elimination of pathogens without causing undue side effects. This tight regulation involves complex interactions between membrane proteins on leukocytes. Members of the signal-regulatory protein (SIRP) family, which are expressed mainly by myeloid cells, provide one example of these regulatory membrane proteins. There are three SIRP-family genes that encode proteins that have similar extracellular regions but different signalling potentials, and are therefore known as 'paired receptors'. In this Review, we describe recent studies defining the ligands of the SIRP-family members, with particular emphasis on relating the molecular interactions of these proteins to their role in immune-cell regulation.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • A. Neil Barclay

  • Marion H. Brown

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free