Skeletal muscle fat oxidation: timing and flexibility are everything

  • Kelley D
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


In order to examine the factors governing the timing and flexibility of skeletal muscle switching between fat and carbohydrate oxidation, Ukropcova et al. studied the effect of glucose and fatty acid availability on the preference for fat oxidation in myocytes cultured from human male quadriceps muscle taken from subjects with varied BMI, fat mass, and insulin sensitivity. The authors found that in vivo insulin sensitivity was related to a higher in vitro capacity for fat oxidation. These findings support the concept that the capacity of skeletal muscle to oxidize fat under appropriate physiological conditions is related to leanness, aerobic fitness, and insulin sensitivity

Author-supplied keywords

  • Human
  • Humans
  • In Vitro
  • Insulin Resistance
  • Lipid Metabolism
  • Male
  • Medicine
  • Models,Biological
  • Muscle Contraction
  • Muscle,Skeletal
  • Oxidation-Reduction
  • Research
  • acid
  • carbohydrate
  • fatty acid
  • fatty acids
  • glucose
  • metabolism
  • muscle
  • nutrition
  • obesity
  • oxidation
  • physiology
  • skeletal muscle

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

There are no full text links


  • D E Kelley

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free