Sleep duration as a risk factor for the development of type 2 diabetes or impaired glucose tolerance: Analyses of the Quebec Family Study

  • Chaput J
  • Despres J
  • Bouchard C
 et al. 
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Abstract

Objective: To examine the long-term relationship between sleep duration and type 2 diabetes or impaired glucose tolerance (IGT). Methods: Body composition measurements and self-reported sleep duration were determined in a longitudinal sample of 276 individuals aged 21 to 64 years followed for a mean of 6 years. Risk factors of type 2 diabetes/IGT over the follow-up were determined and relative risks (RRs) calculated for the development of type 2 diabetes/IGT by sleep duration group. Results: Independent risk factors of type 2 diabetes/IGT over the follow-up included age, obesity, sleep duration, and glucose/insulin homeostasis indicators. Using adults with 7-8 h of sleep as a reference, the adjusted RR for the development of type 2 diabetes/IGT was 2.78 (1.61-4.12) for those with = 9 h of sleep. These elevated RRs remained significant after adjustment for body mass index, waist circumference or percent body fat. Conclusion: Short and long sleeping times are associated with a higher risk of developing type 2 diabetes/IGT, independent of several covariates. These results suggest that sleep duration may represent a novel risk factor for type 2 diabetes/IGT. (C) 2009 Elsevier B.V. All rights reserved

Author-supplied keywords

  • ASSOCIATION
  • Adult
  • Aged
  • BETA-CELL FUNCTION
  • BODY-FAT
  • BODY-MASS
  • Body Composition
  • Body Mass Index
  • CLASSIFICATION
  • Cytokines
  • DEPRIVATION
  • DURATION
  • Denmark
  • FAMILY
  • FAT
  • FOLLOW-UP
  • Glucose
  • Glucose homeostasis
  • Heart
  • Homeostasis
  • Human
  • INSULIN-RESISTANCE
  • Netherlands
  • Obesity
  • Prospective study
  • Quebec
  • RISK-FACTOR
  • Risk
  • Risk Factors
  • Science
  • Sleep
  • Sleep duration
  • Sleep loss
  • Sleep time
  • Time
  • WOMEN
  • Waist Circumference
  • diabetes
  • diagnosis
  • metabolism
  • methods
  • mortality
  • type 2 diabetes

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Authors

  • J P Chaput

  • J P Despres

  • C Bouchard

  • A Astrup

  • A Tremblay

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