Journal article

Small dense LDL cholesterol and coronary heart disease: Results from the Framingham offspring study

Ai M, Otokozawa S, Asztalos B, Ito Y, Nakajima K, White C, Cupples L, Wilson P, Schaefer E ...see all

Clinical chemistry, vol. 56, issue 6 (2010) pp. 967-976

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Abstract

OBJECTIVE: We sought to establish reference values for a new direct assay for small dense LDL cholesterol (sdLDL-C) and to measure sdLDL-C concentrations in patients with established coronary heart disease (CHD) vs controls. METHODS: Direct LDL-C and sdLDL-C were measured in samples from 3188 male and female participants of the Framingham Offspring Study, including 173 men and 74 women with CHD. RESULTS: Postmenopausal status and male sex were associated with higher sdLDL-C concentrations (P < 0.0001). Cholesterol-lowering medication use was more frequent (P < 0.0001) in CHD patients than in controls (46.8% vs 11.4% in men; 35.1% vs 8.8% in women). In men, mean LDL-C was lower inCHDthan in controls (3.22 vs 3.51 mmol/L, P

Author-supplied keywords

  • Aged
  • Anticholesteremic Agents
  • Anticholesteremic Agents: therapeutic use
  • Cholesterol
  • Cohort Studies
  • Coronary Disease
  • Coronary Disease: blood
  • Coronary Disease: drug therapy
  • Female
  • Humans
  • LDL
  • LDL: blood
  • Male
  • Middle Aged
  • Postmenopause
  • Postmenopause: blood
  • adult
  • article
  • blood
  • cholesterol
  • cholesterol blood level
  • controlled study
  • disease association
  • drug therapy
  • female
  • high risk patient
  • human
  • hypocholesterolemic agent
  • ischemic heart disease
  • low density lipoprotein cholesterol
  • major clinical study
  • male
  • postmenopause
  • reference value
  • sex difference
  • therapeutic use

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Authors

  • Masumi Ai

  • Seiko Otokozawa

  • BF Bela F Asztalos

  • Yasuki Ito

  • Katsuyuki Nakajima

  • Charles C White

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