Small stem cells in adult tissues: Very small embryonic-like stem cells stand up!

  • Zuba-Surma E
  • Kucia M
  • Ratajczak J
 et al. 
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This review summarizes information regarding the rare population of very small embryonic-like stem cells {(VSELs)} that has been identified in adult tissues, emphasizing both their unique morphological features and potential biological significance. We focus on their pluripotent nature and expression of markers characteristic for embryonic stem cells {(ESCs),} epiblast {(EP)SCs,} and primordial germ cells {(PGCs).} Furthermore, we will discuss their rank in the developmental hierarchy of the {SC} compartment as well as their relationship to other bone marrow-derived, primitive, nonhematopoietic {SCs} including: (i) endothelial progenitor cells {(EPCs);} (ii) mesenchymal {(M)SCs;} (iii) multipotent adult progenitor cells {(MAPCs);} (iv) marrow-isolated adult multilineage inducible {(MIAMIs)} cells; (v) multipotent adult {(MA)SCs;} and (vi) {OmniCytes.} We will also present different populations of very "small {SCs"} that have been recently described in the literature (e.g., spore-like cells and {Lin(-)/ALDH(high)} long-term repopulating hematopoietic {SCs).}

Author-supplied keywords

  • Imagestream
  • Pluripotent stem cells
  • Small stem cells
  • VSELs; Oct-4

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  • Ewa K. Zuba-Surma

  • Magdalena Kucia

  • Janina Ratajczak

  • Mariusz Z. Ratajczak

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