Space flight, microgravity, stress, and immune responses

  • Sonnenfeld G
  • 2

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Exposure of animals and humans to space flight conditions has resulted in numerous alterations in immunological parameters. Decreases in lymphocyte blastogenesis, cytokine production, and natural killer cell activity have all been reported after space flight. Alterations in leukocyte subset distribution have also been reported after flight of humans and animals in space. The relative contribution of microgravity conditions and stress to the observed results has not been established. Antiorthostatic, hypokinetic, hypodynamic, suspension of rodents and chronic head-down tilt bed-rest of humans have been used to model effects of microgravity on immune responses. After use of these models, some effects of space flight on immune responses, such as decreases in cytokine function, were observed, but others, such as alterations in leukocyte subset distribution, were not observed. These results suggest that stresses that occur during space flight could combine with microgravity conditions in inducing the changes seen in immune responses after space flight. The biological/biomedical significance of space flight induced changes in immune parameters remains to be established. Grant Numbers: NCC2-859, NAG2-933

Author-supplied keywords

  • Adverse Effects
  • Aerospace Medicine
  • Animal
  • Astronauts
  • Bed Rest
  • Head-Down Tilt
  • Human
  • Immune System
  • Immunology
  • Models
  • Physiology
  • Research
  • Responses
  • Space Flight
  • Stress
  • Support,U.S.Gov't,Non-P.H.S.
  • Surgery
  • Weightlessness
  • Weightlessness Simulation
  • natural killer cell activity

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • G Sonnenfeld

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free