This editorial provides an overview of the articles featured in this special issue of Psychopharmacology. One of the articles use a conditioned place preference (CPP) paradigm in mice to determine how the H2O2 scavenger, alpha lipoic acid, affects the acquisition and reconditioning of ethanol-induced CPP. Another paper reports a study of cocaine dependent humans by examining the effects of post-retrieval propranalol on reconsolidation of memory for cocaine craving and cocaine cue reactivity. Overall, the articles in the special Issue pinpoint a wide range of methodological issues confronting studies of reconsolidation and the need to define boundary conditions under which reconsolidation reliably occurs. The therapeutic potential of blocking reconsolidation and enhancing extinction provides a potential mechanism for ameliorating maladaptive associative memories in addiction which may importantly prevent relapse. (PsycINFO Database Record (c) 2013 APA, all rights reserved).
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