Species Selection in Comparative Studies of Aging and Antiaging Research

  • de Magalhães J
  • 29


    Mendeley users who have this article in their library.
  • 9


    Citations of this article.


This chapter focuses on animal species and their use in comparative aging and antiaging researches. Different species of animals age at radically different paces. A salmon will degenerate and die within days after spawning while some turtles, studied for decades, do not show signs of aging. The basic aim of physiological researches in aging animals is to investigate typical human age-related changes. These include the major human killers in old age: cancer, heart, and neurodegenerative diseases. Changes in physiological parameters are interesting for comparative researches of aging. The ultimate objective of aging research is to benefit people. Consequently, choosing species for the comparative biology of aging must be done having Homo sapiens in perspective. As there is a great diversity in the pace of aging among mammals, there is no scientific reason to employ nonmammalian species in the comparative biology of aging. By contrast, incorporating nonmammalian species may lead to the use of species with different biology than humans, and thus, of more dubious use to understand human aging. © 2006 Elsevier Inc. All rights reserved.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • João Pedro de Magalhães

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free