Specific heparin preparations interfere with the simultaneous measurement of ionized magnesium and ionized calcium

  • Lyon M
  • Bremner D
  • Laha T
 et al. 
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Abstract

Objective: To determine whether heparin anticoagulants used for analysis of whole blood ionized calcium would influence the measurement of ionized magnesium. Methods: The effects of zinc heparin, lithium heparin, and electrolyte-balanced heparin on the simultaneous measurement of ionized magnesium and ionized calcium in serum were determined using ion selective electrodes. Results: Time-dependent biases in ionized magnesium and calcium concentrations were apparent with zinc heparin but not with lithium or electrolyte-balanced heparin. Ionized magnesium and calcium concentrations were more significantly influenced by volume-dependent changes in zinc heparin potency than with lithium or electrolyte-balanced heparin. Conclusion: Zinc heparin produces a significant positive bias in the simultaneous determination of ionized magnesium and ionized calcium concentrations. © 1995.

Author-supplied keywords

  • analysis
  • electrolyte-balanced heparin
  • ionized calcium
  • ionized magnesium
  • lithium heparin
  • preanalytical error
  • serum
  • zinc heparin

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Authors

  • Martha E. Lyon

  • Debbie Bremner

  • Thomas Laha

  • Sohail Malik

  • Paul J. Henderson

  • Margaret A. Kenny

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