Spectroscopic evaluation of surface functionalization efficiency in the preparation of mercaptopropyltrimethoxysilane self-assembled monolayers on glass

  • Pallavicini P
  • Dacarro G
  • Galli M
 et al. 
  • 79


    Mendeley users who have this article in their library.
  • 35


    Citations of this article.


Four synthetic protocols have been examined for the preparation of a self-assembled monolayer of propanethiol functions on glass surfaces, through the wet reaction of mercaptopropyltrimethoxysilane (MPTS) on glass slides, in order to determine an optimal method to obtain dense {single bond}SH monolayers for further reaction with maleimide-bearing molecules. We have also demonstrated that the surface density of reactive {single bond}SH groups can be indagated by the coupling reaction with a maleimide-functionalized rhodamine dye and by the examination of the absorption spectra of the glass slides. The reaction of MPTS in dry toluene gives the most dense surface of reactive thiols, among the examined protocols. We have also evidenced that thermal curing of the MPTS functionalized slides induces thiol coupling and {single bond}S{single bond}S{single bond} formation, resulting in a dramatically lowered availability of {single bond}SH groups. © 2008 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • FTIR ATR spectroscopy
  • Glass
  • Maleimide-thiol coupling
  • Self-assembled monolayers
  • Surface chemistry
  • UV-Vis spectroscopy

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Piersandro Pallavicini

  • Giacomo Dacarro

  • Matteo Galli

  • Maddalena Patrini

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free