The spectroscopic properties and the photodynamic activity of 5,10,15,20-tetrakis[4-(3-N,Ndimethylaminopropoxy) phenyl]porphyrin (TAPP) and its tetracationic derivative (TAPP4+) were studied in homogeneous media and in microheterogeneous systems. The results were compared with those of 5,10,15,20-tetra(4-N,N,N-trimethylammoniumphenyl)porphyrin (TMAP4+), which represents an active tetracationic photosensitizer. Absorption and fluorescence studies indicated that the tetrapyrrolic macrocycle retains its individual spectroscopic properties. Interaction with β-cyclodextrin (-CD) was found for TAPP4+ by fluorescence emission. Also, these porphyrins interact with n-heptane/sodium bis(2-ethylhexyl)sulfosuccinate (AOT)/water reverse micelles. Photosensitization ability was evaluated using 9,10-dimethylanthracene in N,N-dimethylformamide and AOT micelles, while tetrasodium 2,2'-(anthracene-9,10-diyl)bis(methylmalonate) was used in aqueous solutions. Also, photosensitized decomposition of l-tryptophan was investigated in these media. In particular, Trp was fast photooxidized by TAPP in a biomimetic media formed by AOT reverse micelles. Therefore, this intrinsically non-charged porphyrin represents an interesting photosensitizer for the photodynamic inactivation of microorganisms. © 2013 Elsevier B.V.
CITATION STYLE
Mora, S. J., Milanesio, M. E., & Durantini, E. N. (2013). Spectroscopic and photodynamic properties of 5,10,15, 20-tetrakis[4-(3-n,n- dimethylaminopropoxy)phenyl]porphyrin and its tetracationic derivative in different media. Journal of Photochemistry and Photobiology A: Chemistry, 270, 75–84. https://doi.org/10.1016/j.jphotochem.2013.07.013
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