Skip to content
Journal article

Sperm characteristics and teratology in rats following vas deferens occlusion with RISUG and its reversal

Lohiya N, Suthar R, Khandelwal A, Goyal S, Ansari A, Manivannan B ...see all

International Journal of Andrology, vol. 33, issue 1 (2010)

  • 11

    Readers

    Mendeley users who have this article in their library.
  • 7

    Citations

    Citations of this article.
  • N/A

    Views

    ScienceDirect users who have downloaded this article.
Sign in to save reference

Abstract

The functional success of the reversal of vas occlusion by styrene maleic anhydride (RISUG), using the solvent vehicle, Dimethyl Sulphoxide (DMSO), has been investigated. Reversal with DMSO was carried out in Wistar albino rats 90 days after bilateral vas occlusion. The body weight, organ weight, sperm characteristics, fertility test and teratology, including skeletal morphology were evaluated in vas occlusion and reversal animals and in F(1) progenies to assess the functional success of the occlusion and reversal. Body weight, organ weight and the cauda epididymal sperm characteristics of vas occlusion and reversal animals and of F(1) progenies were comparable to control. Ejaculated spermatozoa in the vaginal smear showed detached head/tail, acrosomal damage, bent midpiece, bent tail and morphological aberrations in sperm head after vas occlusion, which returned to normal, 90 days after reversal. Monthly fertility test, post-injection showed 0% fertility, which improved gradually and 100% fertility was achieved 90 days after reversal. The fertility/pregnancy/implantation record and skeletal morphology of the offspring were comparable to control. The results suggest functional success and safety of vas occlusion reversal by DMSO.

Author-supplied keywords

  • DMSO
  • Male contraception
  • RISUG
  • Reversal
  • Safety
  • Styrene maleic anhydride
  • Teratology
  • Wistar albino rat

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Authors

  • N. K. Lohiya

  • R. Suthar

  • A. Khandelwal

  • S. Goyal

  • A. S. Ansari

  • B. Manivannan

Cite this document

Choose a citation style from the tabs below