Stereoselectivity of bupivacaine in local anesthetic-sensitive ion channels of peripheral nerve

  • Nau C
  • Vogel W
  • Hempelmann G
 et al. 
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Abstract

The local anesthetic bupivacaine exists in two stereoisomeric forms, R(+)- and S(-)-bupivacaine. Because of its lower cardiac and central nervous system toxicity, attempts were made recently to introduce S(-)-bupivacaine into clinical anesthesia. We investigated stereoselective actions of R(+)-and S(-)-bupivacaine toward two local anesthetic-sensitive ion channels in peripheral nerve, the Na+ and the flicker K+ channel.

Author-supplied keywords

  • Enantiomers
  • Patch-clamp method
  • Piperidine derivatives
  • Rate constants

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Authors

  • Carla Nau

  • Werner Vogel

  • Gunter Hempelmann

  • Michael E. Bräu

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