Sterilization of talc for pleurodesis: Available techniques, efficacy, and cost analysis

  • Kennedy L
  • Vaughan L
  • Steed L
 et al. 
  • 3

    Readers

    Mendeley users who have this article in their library.
  • 27

    Citations

    Citations of this article.

Abstract

Although talc has been used as a pleurodesis agent since 1935, a sterilization protocol has not been established. We obtained USP asbestos-free talc from six different suppliers and sterilized each using dry heat, gamma irradiation, and ethylene oxide gas. Aerobic, anaerobic, and fungal cultures were obtained prior to sterilization, and 1, 30, and 90 days after sterilization. Bacillus species were cultured from all six unsterilized specimens and coagulase-negative Staphylococcus grew from two unsterilized specimens. No growth of organisms was found following any method of sterilization. The cost of sterilization per 5-g packet of talc was $4.74, $7.85, and $16.25 for heat, ethylene oxide, and gamma irradiation, respectively. In conclusion, untreated talc is not sterile. Sterilization by prolonged dry heat exposure, ethylene oxide gas, and gamma irradiation are all effective, with dry heat being the least expensive.

Author-supplied keywords

  • pleurodesis
  • sterilization
  • talc

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

  • PII: S0012369216332226
  • ISSN: 00123692
  • PMID: 7705111
  • PUI: 25115157
  • SCOPUS: 2-s2.0-0028937314
  • SGR: 0028937314

Authors

  • L. Kennedy

  • L. M. Vaughan

  • L. L. Steed

  • S. A. Sahn

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free