Stimulation of angiogenesis resulting from cooperation between macrophages and MDA-MB-231 breast cancer cells: Proposed molecular mechanism and effect of tetrathiomolybdate

  • Joimel U
  • Gest C
  • Soria J
 et al. 
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Abstract

Infiltration by macrophages (Mphi) indicates a poor prognosis in breast cancers, in particular by inducing angiogenesis. Our study aimed 1) to investigate the mechanism by which cooperation between Mphi and aggressive breast cancer cells (MDA-MB-231) induces angiogenesis; 2) to examine the effect of tetrathiomolybdate (TM) on this angiogenic activity.

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Authors

  • Ulrich Joimel

  • Caroline Gest

  • Jeannette Soria

  • Linda Louise Pritchard

  • Jérôme Alexandre

  • Marc Laurent

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