Stimulation site determines the conditioned effects of kindling in rats: Anterior neocortex versus amygdala

  • Barnes S
  • Pinel J
  • Wig G
 et al. 
  • 7

    Readers

    Mendeley users who have this article in their library.
  • 4

    Citations

    Citations of this article.

Abstract

Rats received 53 stimulations to either the left basolateral amygdala (BA) or left anterior neocortex (AN) in one environment (CS+) and 53 sham stimulations (the stimulation lead was attached but no current was delivered) in another environment (CS–), quasirandomly over 54 days. Confirming a previous report [Barnes, S.J., Pinel, J.P., Francis, L.H. & Wig, G.S. (2001) Behav. Neurosci., 115, 1065–1072], as BA kindling progressed, the CS+ began to elicit more defensive behaviours (i.e. less activity, more freezing and avoidance of the CS+) than the CS–, and at the end of the experiment, convulsions elicited in the CS+ were more severe than those elicited in the CS–. Like BA kindling, AN kindling led to less activity in the CS+ ; but unlike BA kindling, AN kindling led to more wet-dog-shakes and less, rather than more, severe convulsions in the CS+. During AN kindling, the mean number of wet-dog-shakes in the CS+ was negatively correlated with the mean convulsion class, suggesting that wet-dog-shakes contribute to the inherent variability of AN kindling. These findings confirm that inherent conditioned effects influence kindled convulsions and interictal behaviour and establish for the first time that the pattern of these conditioned effects is a function of the kindling site.

Author-supplied keywords

  • Animal model
  • Conditioning
  • Context
  • Defensive
  • Epilepsy
  • Neuroplasticity

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Steven J. Barnes

  • John P.J. Pinel

  • Gagan S. Wig

  • Maik C. Stuettgen

  • C. Heike Hölzel

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free