Strategies for salivary cortisol collection and analysis in research with children.

  • Hanrahan K
  • McCarthy A
  • Kleiber C
 et al. 
  • 13

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Abstract

Salivary cortisol has emerged in pediatric research as an easy-to-collect, relatively inexpensive, biologic marker of stress. Cortisol is highly variable and is responsive to a wide range of factors that should be considered when incorporating this measure into research with children. Strategies for sample collection include: (1) standardizing the time for sample collection, including baseline samples; (2) using consistent collection materials and methods; (3) controlling for certain drinks, foods, medications, and diagnoses; and (4) establishing procedures and protocols. Other strategies for laboratory analyses include: (1) selecting the appropriate assay and laboratory; (2) identifying units of measure and norms; and (3) establishing quality controls. These strategies control extraneous variables and produce reliable and valid salivary cortisol results.

Author-supplied keywords

  • Bias (Epidemiology)
  • Child
  • Clinical Nursing Research
  • Clinical Nursing Research: methods
  • Clinical Nursing Research: standards
  • Clinical Protocols
  • Data Collection
  • Data Collection: methods
  • Data Interpretation, Statistical
  • Humans
  • Hydrocortisone
  • Hydrocortisone: analysis
  • Hydrocortisone: secretion
  • Parents
  • Parents: education
  • Patient Education as Topic
  • Patient Selection
  • Pediatric Nursing
  • Questionnaires
  • Reference Values
  • Reproducibility of Results
  • Saliva
  • Saliva: chemistry
  • Saliva: drug effects
  • Sensitivity and Specificity
  • Specimen Handling
  • Specimen Handling: methods
  • Specimen Handling: nursing
  • Specimen Handling: standards
  • Stress, Physiological
  • Stress, Physiological: diagnosis
  • Stress, Physiological: metabolism
  • Time Factors

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Authors

  • Kirsten Hanrahan

  • Ann Marie McCarthy

  • Charmaine Kleiber

  • Susan Lutgendorf

  • Eva Tsalikian

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