Strategy of surgery and radiation therapy for brain metastases.

  • Narita Y
  • Shibui S
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Abstract

Cancer patients with brain metastases have poor prognoses and their
median survival time is about 1 year. Surgery with whole-brain radiation
therapy (WBRT) has been used in the treatment of single brain metastasis
measuring 3 cm or more. Stereotactic radiosurgery (SRS) including
the use of the Gamma knife and Cyberknife is widely used for the
treatment of small and multiple brain metastases; however, recent
clinical studies have revealed that SRS + WBRT is superior to WBRT
or SRS alone in terms of survival time and local tumor control rates.
Here, surgical indications and the strategy of surgery and radiation
therapy are discussed, based on many clinical trials of treatments
for brain metastases. To improve the survival rate and quality of
life for these cancer patients with brain metastases, it is necessary
to choose the most suitable mode of surgery and radiotherapy with
the close cooperation of physicians, surgeons, radiologists, and
neurosurgeons, based on accumulated evidence.

Author-supplied keywords

  • Activities of Daily Living; Anticonvulsants
  • Adjuvant; Steroids
  • adverse effects
  • adverse effects; Evidence-Based Medicine; Humans;
  • mortality/radiotherapy/secondary/surgery; Cranial
  • therapeutic use; Antineoplastic Agents
  • therapeutic use; Brain Neoplasms
  • therapeutic use; Time Factors; Treatment Outcome;

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Authors

  • Yoshitaka Narita

  • Soichiro Shibui

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