Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion

  • Kolter J
  • Feuerstein R
  • Spoeri E
 et al. 
  • 11


    Mendeley users who have this article in their library.
  • 4


    Citations of this article.


Streptococci are common human colonizers with a species-specific mucocutaneous distribution. At the same time, they are among the most important and most virulent invasive bacterial pathogens. Thus, site-specific cellular innate immunity, which is predominantly executed by resident and invading myeloid cells, has to be adapted with respect to streptococcal sensing, handling, and response. In this article, we show that TLR13 is the critical mouse macrophage (MPhi) receptor in the response to group B Streptococcus, both in bone marrow-derived MPhis and in mature tissue MPhis, such as those residing in the lamina propria of the colon and the dermis, as well as in microglia. In contrast, TLR13 and its chaperone UNC-93B are dispensable for a potent cytokine response of blood monocytes to group B Streptococcus, although monocytes serve as the key progenitors of intestinal and dermal MPhis. Furthermore, a specific role for TLR13 with respect to MPhi function is supported by the response to staphylococci, where TLR13 and UNC-93B limit the cytokine response in bone marrow-derived MPhis and microglia, but not in dermal MPhis. In summary, TLR13 is a critical and site-specific receptor in the single MPhi response to beta-hemolytic streptococci.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Julia Kolter

  • Reinhild Feuerstein

  • Evelyne Spoeri

  • Kourosh Gharun

  • Roland Elling

  • Patrick Trieu-Cuot

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free