Stress tolerance in a yeast sterol auxotroph: Role of ergosterol, heat shock proteins and trehalose

  • Swan T
  • Watson K
  • 61


    Mendeley users who have this article in their library.
  • 60


    Citations of this article.


The role of ergosterol in yeast stress tolerance, together with heat shock proteins (hsps) and trehalose, was examined in a sterol auxotrophic mutant of Saccharomyces cerevisiae. Ergosterol levels paralleled viability data, with cells containing higher levels of the sterol exhibiting greater tolerances to heat and ethanol. Although the mutant synthesised hsps and accumulated trehalose upon heat shock to the same levels as the wild-type cells, these parameters did not relate to stress tolerance. These results indicate that the role of ergosterol in stress tolerance is independent of hsps or trehalose. Copyright (C) 1998 Federation of European Microbiological Societies.

Author-supplied keywords

  • Ergosterol
  • Heat shock protein
  • Stress tolerance
  • Trehalose
  • Yeast

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Tracey M. Swan

  • Kenneth Watson

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free