Stretch-activated channels: A mini-review. Are stretch-activated channels an ocular barometer?

  • Kalapesi F
  • Tan J
  • Coroneo M
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Abstract

All cells are subject to physical forces by virtue of their position in a dynamically changing environment. This review outlines the various putative 'mechanosensors', or sensors of pressure cells possess, and discusses in particular the role stretch-activated membrane channels play in pressure recognition and transduction. The widespread occurrence of these channels is discussed and these 'mechanosensors' are related to pressure-related diseases, in particular, glaucoma

Author-supplied keywords

  • Apoptosis
  • Glaucoma
  • Mechanosensors
  • Stretch-activated channels
  • TRAAK

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