Stromal edema in Klf4 conditional null mouse cornea is associated with altered collagen fibril organization and reduced proteoglycans

  • Young R
  • Swamynathan S
  • Boote C
 et al. 
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Abstract

Klf4, one of the highly expressed transcription factors in the mouse cornea, plays an important role in maturation and maintenance of the ocular surface. In this study, the structure and proteoglycan composition of the Klf4 conditional null (Klf4CN) corneal stroma was investigated, to further characterize the previously reported Klf4CN stromal edema.

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Authors

  • Robert D. Young

  • Shivalingappa K. Swamynathan

  • Craig Boote

  • Mary Mann

  • Andrew J. Quantock

  • Joram Piatigorsky

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