Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies

  • Harris C
  • 2

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

The p53 tumor suppressor protein is involved in multiple central cellular processes, including transcription, DNA repair, genomic stability, senescence, cell cycle control, and apoptosis. p53 is functionally inactivated by structural mutations, interaction with viral products, and endogenous cellular mechanisms in the majority of human cancers. This functional inactivation can, in some circumstances, produce resistance to DNA-damaging agents commonly used in cancer chemotherapy and radiotherapeutic approaches. Current research is defining the biochemical pathways through which p53 induces cell cycle arrest and apoptosis. Knowledge of these fundamental processes is leading to the identification of molecular targets toward which multimodality cancer therapies, using chemotherapeutic, immunotherapeutic, and gene-therapeutic strategies, can be based

Author-supplied keywords

  • AGENTS
  • Apoptosis
  • CELL
  • Cell Cycle
  • Combined Modality Therapy
  • DNA
  • DNA Damage
  • DNA Repair
  • DNA,Neoplasm
  • GENE
  • Gene Therapy
  • IDENTIFICATION
  • Immunotherapy
  • MECHANISM
  • MECHANISMS
  • METABOLISM
  • MUTATIONS
  • Neoplasms
  • PATHWAY
  • PATHWAYS
  • PROTEIN
  • STABILITY
  • STATE
  • STATES
  • animal
  • function
  • genes,p53
  • genetics
  • human
  • interaction
  • mutation
  • p53
  • phosphorylation
  • physiology
  • protein p53
  • structure
  • structure-activity relationship
  • target
  • therapy

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

  • PMID: 8841019

Authors

  • C C Harris

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free