Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site

  • Wen X
  • Krause J
  • Leser G
 et al. 
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Abstract

Human metapneumovirus and respiratory syncytial virus cause lower respiratory tract infections. The virus fusion (F) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation. F is also a major target of the neutralizing antibody response. Here we show that a potently neutralizing anti-human metapneumovirus antibody (DS7) binds a structurally invariant domain of F, revealing a new epitope that could be targeted in vaccine development.

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Authors

  • Xiaolin Wen

  • Jens C. Krause

  • George P. Leser

  • Reagan G. Cox

  • Robert A. Lamb

  • John V. Williams

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