China Journal of Chinese Materia Medica, vol. 28, issue 7 (2003) pp. 661-663
To explore the liver-toxic fraction in Rhigoma of Dioscorea bulbifera.The rats were randomized into four groups: control group (20% PVP-water), T001(10% total methanol extraction), F002(5% chloroform fraction) and F003(5% methanol fraction). Direct bilirubin (DBil) and Glutamic-pyruvic transaminase (GPT) were examined, and liver index was measured. The histological and morphological observations were performed with optical and electrical microscope.T001 and F002 showed significant liver toxicity.The chloroform fraction was the liver-toxic fraction of D. bulbifera.
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