Sugar transport through maltoporin of Escherichia coli: Role of the greasy slide

  • Van Gelder P
  • Dumas F
  • Bartoldus I
 et al. 
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The lining of the maltodextrin-specific maltoporin (LamB) channel exhibits a string of aromatic residues, the greasy slide, part of which has been shown previously by crystallography to be involved in substrate binding. To probe the functional role of the greasy slide, alanine scanning mutagenesis has been performed on the six greasy slide residues and Y118 at the channel constriction. The mutants were characterized by an in vivo uptake assay and sugar-induced-current-noise analysis. Crystallographic analysis of the W74A mutant showed no perturbation of the structure. All mutants showed considerably decreased maltose uptake rates in vivo (

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  • Patrick Van Gelder

  • Fabrice Dumas

  • Ingrid Bartoldus

  • Nathalie Saint

  • Alexei Prilipov

  • Mathias Winterhalter

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