Supplementation with complex milk lipids during brain development promotes neuroplasticity without altering myelination or vascular density

  • Guillermo R
  • Yang P
  • Vickers M
 et al. 
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BACKGROUND: Supplementation with complex milk lipids (CML) during postnatal brain development has been shown to improve spatial reference learning in rats.

OBJECTIVE: The current study examined histo-biological changes in the brain following CML supplementation and their relationship to the observed improvements in memory.

DESIGN: The study used the brain tissues from the rats (male Wistar, 80 days of age) after supplementing with either CML or vehicle during postnatal day 10-80. Immunohistochemical staining of synaptophysin, glutamate receptor-1, myelin basic protein, isolectin B-4, and glial fibrillary acidic protein was performed. The average area and the density of the staining and the numbers of astrocytes and capillaries were assessed and analysed.

RESULTS: Compared with control rats, CML supplementation increased the average area of synaptophysin staining and the number of GFAP astrocytes in the CA3 sub-region of the hippocampus (p
CONCLUSION: CML supplementation may enhance neuroplasticity in the CA3 sub-regions of the hippocampus. The brain regions-specific increase of astrocyte may indicate a supporting role for GFAP in synaptic plasticity. CML supplementation did not associate with postnatal white matter development or vascular remodelling.

Author-supplied keywords

  • Brain development
  • Complex milk lipids
  • Dopamine
  • Myelination
  • Neuroplasticity
  • Vascular density

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  • Rosamond B. Guillermo

  • Panzao Yang

  • Mark H. Vickers

  • Paul McJarrow

  • Jian Guan

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