Larson et al investigate the course of Alzheimer disease after initial diagnosis and examine associations hypothesized to correlate with survival among community-dwelling patients with Alzheimer disease. Results demonstrate that survival duration was shorter than predicted on the basis of US population data, especially for persons with onset at relatively younger ages in this sample of community-dwelling elderly persons who received a diagnosis of Alzheimer disease. Features significantly associated with reduced survival at diagnosis were increased severity of cognitive impairment, decreased functional level, history of falls, physical examination findings of frontal release signs, and abnormal gait.
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