Survival rate changes with transfusion of blood products during liver transplantation

  • L. M
  • M.-P. S
  • S. L
 et al. 
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Purpose: To determine whether red blood cell (RBC) or plasma transfusion is associated with the one-year survival rate variation previously detected in liver transplantation. Methods: A retrospective study of 206 consecutive liver transplantations was undertaken. Intraoperative transfusions of blood products were identified. Twenty-seven variables were studied using univariate and multivariate analyses to identify factors that were associated significantly with survival rate. For analysis of one-year survival, the cases were studied according to the transfused blood products. Patients were stratified according to the degree of RBC and plasma transfusion into four groups: more than four units of RBC, one to four units of RBC, plasma transfusion only, and no plasma or RBC transfusions. Results: Patients received an average of 2.8 +/- 3.5 units of RBC and 4.1 +/- 4.1 units of plasma. Thirty-two percent of the patients did not receive any RBC transfusion and 19.4% did not receive any blood products. The one-year survival rate was 81.9% for all patients and 97.4% for patients without any transfusions. Of the 27 variables evaluated, only RBC and plasma transfusions were associated with significant decrease in the one-year survival rate, which was seen in the group who received only plasma (76.9%, P = 0.014) and the group who received more than four units of RBC (62.5%, P < 0.0001). Conclusion: Although we cannot demonstrate causality, our analysis shows that our one-year survival rate following liver transplantation decreased significantly with the intraoperative transfusion of any amount of plasma or more than four units of RBC.

Author-supplied keywords

  • *blood transfusion
  • *liver transplantation
  • adult
  • article
  • controlled study
  • erythrocyte transfusion
  • female
  • human
  • major clinical study
  • male
  • patient coding
  • peroperative care
  • plasma transfusion
  • priority journal
  • retrospective study
  • statistical analysis
  • survival rate

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  • Massicotte L.

  • Sassine M.-P.

  • Lenis S.

  • Seal R.F.

  • Roy A.

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