Sustained attention abnormalities in breast cancer survivors with cognitive deficits post chemotherapy: An electrophysiological study

  • Kam J
  • Brenner C
  • Handy T
 et al. 
  • 63

    Readers

    Mendeley users who have this article in their library.
  • 9

    Citations

    Citations of this article.

Abstract

Objective: Many breast cancer survivors (BCS) report cognitive problems following chemotherapy, yet controversy remains concerning which cognitive domains are affected. This study investigated a domain crucial to daily function: the ability to maintain attention over time. Methods: We examined whether BCS who self-reported cognitive problems up to 3 years following cancer treatment (n = 19) performed differently from healthy controls (HC, n = 12) in a task that required sustained attention. Participants performed a target detection task while periodically being asked to report their attentional state. Electroencephalogram was recorded during this task and at rest. Results: BCS were less likely to maintain sustained attention during the task compared to HC. Further, the P3 event-related potential component elicited by visual targets during the task was smaller in BCS relative to HC. BCS also displayed greater neural activity at rest. Conclusions: BCS demonstrated an abnormal pattern of sustained attention and resource allocation compared to HC, suggesting that attentional deficits can be objectively observed in breast cancer survivors who self-report concentration problems. Significance: These data underscore the value of EEG combined with a less traditional measure of sustained attention, or attentional states, as objective laboratory tools that are sensitive to subjective complaints of chemotherapy-related attentional impairments.

Author-supplied keywords

  • Adjuvant chemotherapy
  • Breast cancer
  • Cognitive deficits
  • Mind wandering
  • P300 ERP
  • Rest EEG
  • Sustained attention

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free