Sustained neuronal activation raises oxidative metabolism to a new steady-state level: evidence from 1H NMR spectroscopy in the human visual cortex.

  • Mangia S
  • Tkác I
  • Gruetter R
 et al. 
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Abstract

To date, functional 1H NMR spectroscopy has been utilized to report the time courses of few metabolites, primarily lactate. Benefiting from the sensitivity offered by ultra-high magnetic field (7 T), the concentrations of 17 metabolites were measured in the human visual cortex during two paradigms of visual stimulation lasting 5.3 and 10.6 mins. Significant concentration changes of approximately 0.2 micromol/g were observed for several metabolites: lactate increased by 23%+/-5% (P

Author-supplied keywords

  • Adult
  • Amino Acids
  • Aspartic Acid
  • Female
  • Humans
  • Lactic Acid
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • Malates
  • Male
  • Neurons
  • Oxidation-Reduction
  • Oxygen
  • Visual Cortex

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Authors

  • Silvia Mangia

  • Ivan Tkác

  • Rolf Gruetter

  • Pierre-Francois Van de Moortele

  • Bruno Maraviglia

  • Kâmil Uğurbil

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