Symmetrical thalamic calcifications in a monozygotic twin: Case report and literature review

  • Buldini B
  • Drigo P
  • Via L
 et al. 
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We report the occurrence of symmetrical thalamic calcifications (STC) in one of a pair of monozygotic twins born at term without evidence of pre- or peri-natal asphyxia. STC is known to be an extremely rare condition in infants. Judging from the few cases reported in the literature, the clinical presentation is very severe: low Apgar score, no spontaneous movements, spasticity or marked hypotonia, impaired suck and swallow, facial diplegia. The prognosis is also very poor. The etiology is still a matter of debate: genetic, infectious, toxic or hypoxic-ischemic insults have been hypothesized. In our case, the presence of the lesion in one of a pair of monozygotic twins would rule out any genetic origin, nor was there any evidence of toxic or infectious disease. The only potential risk factor for fetal damage was hypoxic-ischemic insult related to the twin pregnancy. © 2004 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Hypoxic-ischemic encephalopathy
  • Thalamic calcifications
  • Twin pregnancy

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  • Barbara Buldini

  • Paola Drigo

  • Luigi Dalla Via

  • Milena Calderone

  • Anna Maria Laverda

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