We report the occurrence of symmetrical thalamic calcifications (STC) in one of a pair of monozygotic twins born at term without evidence of pre- or peri-natal asphyxia. STC is known to be an extremely rare condition in infants. Judging from the few cases reported in the literature, the clinical presentation is very severe: low Apgar score, no spontaneous movements, spasticity or marked hypotonia, impaired suck and swallow, facial diplegia. The prognosis is also very poor. The etiology is still a matter of debate: genetic, infectious, toxic or hypoxic-ischemic insults have been hypothesized. In our case, the presence of the lesion in one of a pair of monozygotic twins would rule out any genetic origin, nor was there any evidence of toxic or infectious disease. The only potential risk factor for fetal damage was hypoxic-ischemic insult related to the twin pregnancy. © 2004 Elsevier B.V. All rights reserved.
CITATION STYLE
Buldini, B., Drigo, P., Via, L. D., Calderone, M., & Laverda, A. M. (2005). Symmetrical thalamic calcifications in a monozygotic twin: Case report and literature review. Brain and Development, 27(1), 66–69. https://doi.org/10.1016/j.braindev.2004.04.002
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