Journal article

Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis.

Raza K, Scheel-Toellner D, Lee C, Pilling D, Curnow S, Falciani F, Trevino V, Kumar K, Assi L, Lord J, Gordon C, Buckley C, Salmon M ...see all

Arthritis Res Ther, vol. 8, issue 4 (2006) pp. 1-7

  • 31


    Mendeley users who have this article in their library.
  • 56


    Citations of this article.
Sign in to save reference


Synovial leukocyte apoptosis is inhibited in established rheumatoid arthritis (RA). In contrast, high levels of leukocyte apoptosis are seen in self-limiting crystal arthritis. The phase in the development of RA at which the inhibition of leukocyte apoptosis is first apparent, and the relationship between leukocyte apoptosis in early RA and other early arthritides, has not been defined. We measured synovial fluid leukocyte apoptosis in very early arthritis and related this to clinical outcome. Synovial fluid was obtained at presentation from 81 patients with synovitis of < or = 3 months duration. The percentages of apoptotic neutrophils and lymphocytes were assessed on cytospin preparations. Patients were assigned to diagnostic groups after 18 months follow-up. The relationship between leukocyte apoptosis and patient outcome was assessed. Patients with early RA had significantly lower levels of neutrophil apoptosis than patients who developed non-RA persistent arthritis and those with a resolving disease course. Similarly, lymphocyte apoptosis was absent in patients with early RA whereas it was seen in patients with other early arthritides. The inhibition of synovial fluid leukocyte apoptosis in the earliest clinically apparent phase of RA distinguishes this from other early arthritides. The mechanisms for this inhibition may relate to the high levels of anti-apoptotic cytokines found in the early rheumatoid joint (e.g. IL-2, IL-4, IL-15 GMCSF, GCSF). It is likely that this process contributes to an accumulation of leukocytes in the early rheumatoid lesion and is involved in the development of the microenvironment required for persistent RA.

Author-supplied keywords

  • Adult
  • Aged
  • Apoptosis
  • Arthritis
  • Arthritis: physiopathology
  • Diagnosis
  • Differential
  • Early Diagnosis
  • Female
  • Humans
  • Leukocytes
  • Longitudinal Studies
  • Lymphocytes
  • Male
  • Middle Aged
  • Neutrophils
  • Rheumatoid
  • Rheumatoid: diagnosis
  • Rheumatoid: physiopathology
  • Synovial Fluid
  • Synovial Fluid: cytology
  • Time Factors

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Karim Raza

  • Dagmar Scheel-Toellner

  • Chi-Yeung Lee

  • Darrell Pilling

  • S John Curnow

  • Francesco Falciani

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free