Synthesis and antimalarial property of orally active phenoxazinium salts

  • Takasu K
  • Shimogama T
  • Satoh C
 et al. 
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Abstract

Phenoxazinium salts were found to display good antimalarial efficacy in vivo against Plasmodium berghei. Several compounds provided 100% parasitemia clearance at a dose of 20-30 mg kg-1x4 days (ip) and good survival effects without obvious acute toxicity. They also showed excellent potency by oral administration. A preliminary pharmacokinetic study revealed that the oral availability of 1a was excellent.

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