Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety

  • Joksović M
  • Marković V
  • Juranić Z
 et al. 
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Abstract

A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] α-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 1l exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines. © 2009 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Amino acids
  • Cytotoxicity
  • Ferrocenyl pyrazole

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