Synthesis, characterization and cytotoxicity studies of chitosan-coated tea polyphenols nanoparticles

  • Liang J
  • Li F
  • Fang Y
 et al. 
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Chitosan nanoparticles (CS-NPs) were prepared by ionic gelation method using carboxymethyl chitosan and chitosan hydrochloride as carriers of tea polyphenols. The characteristics of chitosan-coated tea polyphenols nanoparticles (CS-TP NPs) were determined by using transmission electron microscopy (TEM) and FT-IR spectroscopy. It was found that the synthesized CS-TP NPs were non-spherical in shape with an average size of 407+/-50nm. Meanwhile, the drug content and encapsulation rate of the nanoparticles was 8-16% and 44-83%, respectively. These CS-TP NPs also demonstrated sustained release of tea polyphenols in PBS. The antitumor of CS-TP NPs towards HepG2 cancer cells was investigated. The result showed that CS-TP NPs retained significant antitumor activities.

Author-supplied keywords

  • Chitosan/analogs & derivatives/*chemistry
  • Chlorides/chemistry
  • Flavonoids/*chemistry
  • Hep G2 Cells
  • Humans
  • Ions
  • Light
  • Microscopy, Electron, Transmission/methods
  • Nanoparticles/chemistry
  • Nanotechnology/methods
  • Phenols/*chemistry
  • Polyphenols
  • Scattering, Radiation
  • Spectroscopy, Fourier Transform Infrared/methods
  • Tea
  • Tetrazolium Salts/pharmacology
  • Thiazoles/pharmacology

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  • J Liang

  • F Li

  • Y Fang

  • W Yang

  • X An

  • L Zhao

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