Synthesis and Characterization of Novel Poly ( ester carbonate ) s Based on Pentaerythritol

  • Xie Z
  • Lu C
  • Chen X
 et al. 
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Abstract

Novel poly(ester carbonate)s were synthesized by the ring-opening poly- merization of L-lactide and functionalized carbonate monomer 9-phenyl-2,4,8,10-tet- raoxaspiro[5,5]undecan-3-one derived from pentaerythritol with diethyl zinc as an initiator. 1H NMR analysis revealed that the carbonate content in the copolymer was almost equal to that in the feed. DSC results indicated that Tg of the copolymer increased with increasing carbonate content in the copolymer. Moreover, the protect- ing benzylidene groups in the copolymer poly(L-lactide-co-9-phenyl-2,4,8,10-tetraoxas- piro[5,5]undecan-3-one) were removed by hydrogenation with palladium hydroxide on activated charcoal as a catalyst to give a functional copolymer, poly(L-lactide-co-2,2- dihydroxylmethyl-propylene carbonate), containing pendant primary hydroxyl groups. Complete deprotection was confirmed by 1H NMR and FTIR spectroscopy. The in vitro degradation rate of the deprotected copolymers was faster than that of the protected copolymers in the presence of proteinase K. The cellmorphology and viability on a copol- ymer film evaluated with ECV-304 cells showed that poly(ester carbonate)s derived from pentaerythritol are good biocompatible materials suitable for biomedical applica- tions

Author-supplied keywords

  • biodegradable
  • bonates
  • functionalization of polymers
  • pentaerythritol
  • polycar-
  • polylactide

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Authors

  • Zhigang Xie

  • Changhai Lu

  • Xuesi Chen

  • L I Chen

  • Y U Wang

  • Xiuli Hu

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