Synthesis and incorporation of a furan-modified adenosine building block for DNA interstrand crosslinking

  • Jawalekar A
  • Op De Beeck M
  • Van Delft F
 et al. 
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Abstract

2'-O-(3-(Furan-2-yl)propyl)adenosine was synthesized and evaluated for interstrand crosslink (ICL) formation in DNA duplexes. In situ oxidation of the furan moiety with NIS showed rapid crosslink formation to dA and dC, while dT and dG were inactive.

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Authors

  • Anup M. Jawalekar

  • Marieke Op De Beeck

  • Floris L. Van Delft

  • Annemieke Madder

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