Synthesis of isogranulatimide analogues possessing a pyrrole moiety instead of an imidazole heterocycle

  • Hugon B
  • Pfeiffer B
  • Renard P
 et al. 
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An efficient four step synthesis from commercial indoles of isogranulatimide analogues is reported. In the new compounds, the imidazole moiety is replaced by a pyrrole unit, the indole part is substituted or not in 5-position and the nitrogen of the imide moiety bears or not a methyl substituent. © 2003 Elsevier Science Ltd. All rights reserved.

Author-supplied keywords

  • G2 checkpoint inhibitors
  • Isogranulatimide
  • Pyrrolo[3,4-c]carbazole

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  • Bernadette Hugon

  • Bruno Pfeiffer

  • Pierre Renard

  • Michelle Prudhomme

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