Figure presented Pactamycin, one of the most complex and densely functionalized aminocyclitol antibiotics known, presents synthetic challenges that include reactivity and sterics, relative and absolute stereochemistry, and functional group compatibility and protection. An approach is reported that features four different types of (cyclopentane) face selective functionalization reactions and results in a polyfunctionalized and appropriately protected intermediate that incorporates all the core carbons and the oxygenated functionality of the target. © 2007 American Chemical Society.
CITATION STYLE
Knapp, S., & Younong, Y. (2007). Synthesis of the oxygenated pactamycin core. Organic Letters, 9(7), 1359–1362. https://doi.org/10.1021/ol0702472
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