The synthesis of roeharmine and (-)-1,2,3,4-tetrahydroroeharmine

  • Reddy M
  • Cook J
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Abstract

The total synthesis of roeharmine 1 as well as an enantiospecific synthesis of (-)-1,2,3,4-tetrahydroroeharmine 2 has been achieved via the Pictet-Spengler reaction as a key step. The optical rotation of synthetic (-)-2 was found to be higher than that reported for the natural product. A possible mechanism for the racemization of 2 upon exposure to acid has been proposed and serves as a warning to alkaloid chemists who isolate ring-A alkoxylated indole alkaloids under acidic conditions. © 1994.

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Authors

  • M. Sreenivasa Reddy

  • James M. Cook

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